Article

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin

2021-06-11

Abstract excerpt

<h4>Summary</h4> Glioblastoma recurrence originates from invasive cells at the tumour margin that escape surgical debulking, but their biology remains poorly understood. Here we generated three somatic mouse models recapitulating the main glioblastoma driver mutations to characterise margin cells. We find that, regardless of genetics, tumours converge on a common set of neural- like cellular states. However, bulk...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e33de194-48f3-5363-8724-1c8e9e4a9987
DOI: 10.1101/2021.06.11.447915

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative marginDOI 10.1101/2021.06.11.447915Read

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative marginSemantic proximity Read

Gliomagenesis mimics an injury response orchestrated by neural crest-like cellsSemantic proximity Read

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneitySemantic proximity Read

Neuronal and tumourigenic boundaries of glioblastoma plasticitySemantic proximity Read

Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cellsSemantic proximity Read

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenceSemantic proximity Read

Essential Gene Pathways for Glioblastoma Stem Cells: Clinical Implications for Prevention of Tumor RecurrenceSemantic proximity Read

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human GlioblastomaSemantic proximity Read

The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central TumourSemantic proximity Read

Single-Cell RNAseq analysis of infiltrating neoplastic cells at the migrating front of human glioblastomaSemantic proximity Read

Lineage and Spatial Mapping of Glioblastoma-associated ImmunitySemantic proximity Read

Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiationSemantic proximity Read