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Article

Time-lapse phenotyping of invasive glioma cells ex vivo reveals subtype-specific movement patterns guided by tumor core signaling.

Experimental cell research - 10 Dec 2016

Fayzullin Artem, Tuvnes Frode A, Skjellegrind Håvard K, Behnan Jinan, Mughal Awais A, Langmoen Iver A, Vik-Mo Einar O

Abstract excerpt

The biology of glioblastoma invasion and its mechanisms are poorly understood. We demonstrate using time-lapse microscopy that grafting of glioblastoma (GBM) tumorspheres into rodent brain slices results in experimental ex vivo tumors with invasive properties that recapitulate the invasion observed after orthotopic transplantation into the rodent brain. The migratory movements and mitotic patterns were clearly...

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Identifiers

PMID: 27515001
DOI: 10.1016/j.yexcr.2016.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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