Article

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

2023-09-17

Abstract excerpt

The growth of a tumor is tightly linked to the distribution of its cells along a continuum of activation states. Here, we systematically decode the activation state architecture (ASA) in a glioblastoma (GBM) patient cohort through comparison to adult murine neural stem cells. Modelling of these data forecast how tumor cells organize to sustain growth and identifies rate of activation as the main predictor of growt...

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Literature Corpus work: fe0dc01c-d25d-5643-bb35-8c00e332408d
DOI: 10.1101/2023.09.15.557713

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