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Article

Shared Genetic Architectures and Causal Associations Between Diabetic Retinopathy Progression and Frailty-Related Phenotypes.

Genes - 31 May 2026

Luo Renxin, Yu Xiaotong, Huang Chen, Tan Shumei, Tseng Yulin, Feng Yue, Li Xuemin

Abstract excerpt

Background/Objectives: Observational studies have reported comorbidity between diabetic retinopathy (DR) and physical frailty, but their genetic interplay remains incompletely understood. This study evaluated shared genetic architecture and potential causal relationships between DR severity and frailty-related phenotypes (FRPs). Methods: GWAS summary statistics were analyzed for four DR phenotypes (broad DR,...

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Share to Diabetic Retinopathy
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frailty

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42353808
DOI: 10.3390/genes17060642
PMCID: PMC13299082

Genes

HGS
AIF1
BCL2L15
C2
EHMT2
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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