Article
Tensor decomposition for multiple-tissue gene expression experiments.
Nature genetics - 1 Sept 2016
Hore Victoria, Viñuela Ana, Buil Alfonso, Knight Julian, McCarthy Mark I, Small Kerrin, Marchini Jonathan
Abstract excerpt
Genome-wide association studies of gene expression traits and other cellular phenotypes have successfully identified links between genetic variation and biological processes. The majority of discoveries have uncovered cis-expression quantitative trait locus (eQTL) effects via mass univariate testing of SNPs against gene expression in single tissues. Here we present a Bayesian method for multiple-tissue...
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