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Article

Partitioning genetic pleiotropy within tissue-specific regulatory patterns.

Cell genomics - 8 Apr 2026

Panja Prasun, Biswas Diptanil, Bhattacharjee Samsiddhi

Abstract excerpt

GWAS-associated variants of related complex traits indicate the presence of pleiotropic clusters often related to tissue-specific epigenomic profiles. The authors introduce J-PEP, a novel framework that enables tissue-aware interpretation of complex trait genetic architecture and PEPA, a cross-modal validation metric. J-PEP factorizes trait and tissue data matrices jointly to identify soft clusters of SNPs that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41956071
DOI: 10.1016/j.xgen.2026.101212
PMCID: PMC13069840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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