Article

Combinatorial logic of Nav channels in nociceptor excitability: Different degrees of synergy define distinct neuronal groups

2026-04-04

Abstract excerpt

Despite the genetic validation of voltage-gated sodium (Nav) channels as targets for pain therapy, single-channel subtype inhibition in clinical trials has yielded limited efficacy. Because Nav1.7 and Nav1.8 are thought to act in a coupled manner in ignition and subsequent regenerative, overshooting depolarization underlying the action potential of nociceptors, we utilized dynamic clamp, which permits precisely ca...

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Literature Corpus work: 4e62ee4e-3193-5b93-89da-d1252d69dd68
DOI: 10.64898/2026.04.04.716368

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