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Article

Stem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability.

Brain : a journal of neurology - 5 Jan 2023

Alsaloum Matthew, Labau Julie I R, Liu Shujun, Effraim Philip R, Waxman Stephen G

Abstract excerpt

Effective treatment of pain remains an unmet healthcare need that requires new and effective therapeutic approaches. NaV1.7 has been genetically and functionally validated as a mediator of pain. Preclinical studies of NaV1.7-selective blockers have shown limited success and translation to clinical studies has been limited. The degree of NaV1.7 channel blockade necessary to attenuate neuronal excitability and...

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Identifiers

PMID: 35088838
DOI: 10.1093/brain/awac031
PMCID: PMC10060693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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