Stem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability.

doi:10.1093/brain/awac031

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Article

Stem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability.

Brain : a journal of neurology - 5 Jan 2023

Alsaloum Matthew, Labau Julie I R, Liu Shujun, Effraim Philip R, Waxman Stephen G

Abstract excerpt

Effective treatment of pain remains an unmet healthcare need that requires new and effective therapeutic approaches. NaV1.7 has been genetically and functionally validated as a mediator of pain. Preclinical studies of NaV1.7-selective blockers have shown limited success and translation to clinica...

Topics

Humans
Erythromelalgia
NAV1.7 Voltage-Gated Sodium Channel
Mutation
Pain
Sensory Receptor Cells
Ganglia, Spinal

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