Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.

doi:10.1152/jn.00898.2016

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Article

Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.

Journal of neurophysiology - 1 Apr 2017

Estacion Mark, Waxman Stephen G

Abstract excerpt

The Nav1.7 sodium channel is preferentially expressed within dorsal root ganglion (DRG) and sympathetic ganglion neurons. Gain-of-function mutations that cause the painful disorder inherited erythromelalgia (IEM) shift channel activation in a hyperpolarizing direction. When expressed within DRG neurons, these mutations produce a depolarization of resting membrane potential (RMP). The biophysical basis for the...

Topics

Animals
Biophysics
Electric Stimulation
Ganglia, Spinal
Humans
Membrane Potentials
Models, Neurological
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Neurons
Patch-Clamp Techniques

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Identifiers

PMID: 28148645
DOI: 10.1152/jn.00898.2016
PMCID: PMC5380781

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