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Article

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2017

Osteen Jeremiah D, Sampson Kevin, Iyer Vivek, Julius David, Bosmans Frank

Abstract excerpt

The Nav1.1 voltage-gated sodium channel is a critical contributor to excitability in the brain, where pathological loss of function leads to such disorders as epilepsy, Alzheimer's disease, and autism. This voltage-gated sodium (Nav) channel subtype also plays an important role in mechanical pain signaling by primary afferent somatosensory neurons. Therefore, pharmacologic modulation of Nav1.1 represents a...

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Identifiers

PMID: 28607094
DOI: 10.1073/pnas.1621263114
PMCID: PMC5495237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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