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Article

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Sept 2014

Huang Jianying, Yang Yang, Dib-Hajj Sulayman D, van Es Michael, Zhao Peng, Salomon Jody, Drenth Joost P H, Waxman Stephen G

Abstract excerpt

Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability. Genetic and functional studies have established a critical contribution of Nav1.7 to human pain disorders. We have now characterized a novel Nav1.7 mutation (R1279P) from a female human subject with distal limb pain, in which depolarized fast inactivation overrides impaired activation to produce...

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Identifiers

PMID: 25209274
DOI: 10.1523/JNEUROSCI.2773-14.2014
PMCID: PMC6615500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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