Article

Equivalent excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

2022-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but efforts to treat pain by inhibiting Na V 1.7 pharmacologically have largely failed. This may reflect the variable contribution of Na V 1.7 to nocicept...

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Literature Corpus work: 7d4dd99e-4c92-5145-854c-f37229a04cca
DOI: 10.1101/2022.10.04.510784

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