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Article

Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.

Scientific reports - 20 Dec 2021

Alsaloum Matthew, Labau Julie I R, Liu Shujun, Estacion Mark, Zhao Peng, Dib-Hajj Fadia, Waxman Stephen G

Abstract excerpt

The inhibition of voltage-gated sodium (NaV) channels in somatosensory neurons presents a promising novel modality for the treatment of pain. However, the precise contribution of these channels to neuronal excitability, the cellular correlate of pain, is unknown; previous studies using genetic knockout models or pharmacologic block of NaV channels have identified general roles for distinct sodium channel...

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Identifiers

PMID: 34930944
DOI: 10.1038/s41598-021-03608-x
PMCID: PMC8688473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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