Article

A population of in silico models identifies the interplay between Nav 1.8 conductance and potassium currents as key in regulating human dorsal root ganglion neuron excitability

2022-01-27

Abstract excerpt

<h4>Background: </h4> The Nav 1.8 sodium channel has a key role in generating repetitive action potentials in nociceptive human dorsal root ganglion neurons. Nav 1.8 is differentiated from other voltage-gated sodium channels by its unusually slow inactivation kinetics and depolarised voltage-dependence of activation. These features are particularly pronounced in the human Nav 1.8 channel and allow the channel to r...

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Literature Corpus work: 7c409359-4287-5aae-9f0c-666047720b45
DOI: 10.12688/f1000research.74551.1

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A population of in silico models identifies the interplay between Nav 1.8 conductance and potassium currents as key in regulating human dorsal root ganglion neuron excitabilityDOI 10.12688/f1000research.74551.1Read

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