Article

Nav1.7 gating in human iPSC derived sensory neurons: an experimental and computational study

2020-08-04

Abstract excerpt

Chronic pain is a global healthcare problem with a huge societal impact. Its management remains unsatisfactory, with no single treatment clinically approved in most cases. In this study we use an in vitro experimental model of erythromelalgia consisting of sensory neurons derived from human induced pluripotent stem cells obtained from a patient (carrying the mutation F1449V) and a control subject. We combine neur...

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Literature Corpus work: cef77cf1-dd72-5de3-b712-ab0d0768a0d9
DOI: 10.1101/2020.08.04.235861

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