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Article

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability

21 May 2017

Abstract excerpt

Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the...

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PMID: 28530638
DOI: 10.1172/jci92373

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