Article

Evolutionary origin, cyclic peptide targeting and physiological activation of Peptidyl Arginine Deiminase 4

2020-01-01

Abstract excerpt

Five peptidylarginine deiminases (PADIs), regulating diverse aspects of human physiology, catalyse the post-translational modification citrullination in mammals. Deregulation of citrullination underlies the development of diverse pathologies and PADI4 is of particular medical interest in autoimmune diseases and in cancer. PADI activation is understood biochemically at the level of the crystal structure where allos...

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Literature Corpus work: 4e59a16a-e5f2-55d7-89d9-e4f8feb7e5df
DOI: 10.7488/era/468

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