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Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

3 Mar 2010

Abstract excerpt

OBJECTIVE: To address mechanisms that control the activity of human peptidyl arginine deiminase type 4 (PAD-4). METHODS: PAD-4 autocitrullination was determined by anti-modified citrulline immunoblotting, using purified recombinant and endogenous PAD-4 from activated human primary neutrophils and cell lines expressing PAD-4. The citrullination sites in PAD-4 were determined by mass spectrometry. Mechanisms of...

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PMID: 20201080
DOI: 10.1002/art.27439

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