Article

Protein citrullination was introduced into animals by horizontal gene transfer from cyanobacteria

2020-06-15

Abstract excerpt

Protein post-translational modifications (PTMs) add an enormous amount of sophistication to biological systems but their origins are largely unexplored. Citrullination, a key regulatory mechanism in human physiology and pathophysiology, is particularly enigmatic in an evolutionary context. The citrullinating enzymes peptidylarginine deiminases (PADIs) are ubiquitous across vertebrates but absent from yeast, worms...

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Literature Corpus work: 8542493d-e3ab-5c4e-bffa-ec43d81feec0
DOI: 10.1101/2020.06.13.150037

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