Article

Decoding isozyme-specific substrate recognition in protein arginine deiminases by proteome-wide citrullination mapping

2025-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Protein arginine deiminases (PADs) convert arginine to citrulline, altering protein structure and function. Of the five human isozymes, PAD1–4 are catalytically active with distinct tissue-specificities, yet isozyme-specific substrate recognition remains poorly defined. We profiled PAD1–4 substrate landscapes via mass spectrometry, identifying ∼30,000 citrullination sites across ∼5,500 proteins....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d85ca22-8245-598e-961a-8ffb1fb19309
DOI: 10.64898/2025.12.01.691579

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding isozyme-specific substrate recognition in protein arginine deiminases by proteome-wide citrullination mappingDOI 10.64898/2025.12.01.691579Read

A quantitative and site-specific atlas of the in vivo citrullinome reveals widespread existence of citrullinationSemantic proximity Read

Peptidyl Arginine Deiminases in Chronic Diseases: A Focus on Rheumatoid Arthritis and Interstitial Lung DiseaseSemantic proximity Read

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activationSemantic proximity Read

Citrullination and the protein code: crosstalk between post-translational modifications in cancerSemantic proximity Read

PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritisSemantic proximity Read

PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseSemantic proximity Read

Protein Arginine Deiminase 4 Antagonizes Methylglyoxal-induced Histone GlycationSemantic proximity Read

Structural Insight into the Function of Human Peptidyl Arginine Deiminase 6Semantic proximity Read

Development of Motif-Specific Monoclonal Antibodies for Global Protein Citrullination Detection with Minimal Cross-Reactivity to HomocitrullinationSemantic proximity Read

Evolution of a mass spectrometry-grade protease with PTM-directed specificity.Semantic proximity Read

Arginine citrullination at the C-terminal domain controls RNA polymerase II transcriptionSemantic proximity Read

Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfacesSemantic proximity Read