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Article

Peptidylarginine deiminase 4 and citrullination in health and disease.

Autoimmunity reviews - 1 Jan 2010

Anzilotti Consuelo, Pratesi Federico, Tommasi Cristina, Migliorini Paola

Abstract excerpt

Deimination is catalyzed by a family of calcium binding enzymes, called peptidylarginine deiminases (PADs). Among these, the PAD4 isoform has been more extensively studied for its role in some autoimmune diseases. PAD4 is localized in the cytoplasm of monocytes, T and B cells, neutrophils, eosinophils and NK cells and can move to the nucleus upon cell activation. PAD4 plays a physiological role in gene regulation...

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Source

Identifiers

PMID: 19540364
DOI: 10.1016/j.autrev.2009.06.002

Genes

PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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