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Article

Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays.

Genome biology - 1 Jan 2008

Staaf Johan, Lindgren David, Vallon-Christersson Johan, Isaksson Anders, Göransson Hanna, Juliusson Gunnar, Rosenquist Richard, Höglund Mattias, Borg Ake, Ringnér Markus

Abstract excerpt

We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina p...

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Identifiers

PMID: 18796136
DOI: 10.1186/gb-2008-9-9-r136
PMCID: PMC2592714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18796136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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