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Article

Simple binary segmentation frameworks for identifying variation in DNA copy number.

BMC bioinformatics - 30 Oct 2012

Yang Tae Young

Abstract excerpt

BACKGROUND: Variation in DNA copy number, due to gains and losses of chromosome segments, is common. A first step for analyzing DNA copy number data is to identify amplified or deleted regions in individuals. To locate such regions, we propose a circular binary segmentation procedure, which is based on a sequence of nested hypothesis tests, each using the Bayesian information criterion. RESULTS: Our procedure is...

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Identifiers

PMID: 23107320
DOI: 10.1186/1471-2105-13-277
PMCID: PMC3571941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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