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Article

Parent-specific copy number in paired tumor-normal studies using circular binary segmentation.

Bioinformatics (Oxford, England) - 1 Aug 2011

Olshen Adam B, Bengtsson Henrik, Neuvial Pierre, Spellman Paul T, Olshen Richard A, Seshan Venkatraman E

Abstract excerpt

MOTIVATION: High-throughput techniques facilitate the simultaneous measurement of DNA copy number at hundreds of thousands of sites on a genome. Older techniques allow measurement only of total copy number, the sum of the copy number contributions from the two parental chromosomes. Newer single nucleotide polymorphism (SNP) techniques can in addition enable quantifying parent-specific copy number (PSCN). The raw...

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PMID: 21666266
DOI: 10.1093/bioinformatics/btr329
PMCID: PMC3137217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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