Article

High throughput small molecule screening reveals NRF2-dependent and - independent pathways of cellular stress resistance

2019-09-22

Abstract excerpt

Biological aging is the dominant risk factor for most chronic diseases. Development of anti-aging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl me...

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Literature Corpus work: 4e3ecd95-72d4-5995-b82f-da404a7fd6bd
DOI: 10.1101/778548

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