Article
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.
Aging cell - 1 Feb 2017
Desjardins David, Cacho-Valadez Briseida, Liu Ju-Ling, Wang Ying, Yee Callista, Bernard Kristine, Khaki Arman, Breton Lionel, Hekimi Siegfried
Abstract excerpt
Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N-acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake,...
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