Viral load-driven systemic immune exhaustion is an enabler of antibody breadth in HIV infection

Abstract excerpt

A broadly neutralizing response to a human immunodeficiency virus (HIV) vaccine is a major goal of the field, yet the determinants of antibody breadth remain poorly defined. Antibody responses to HIV evolve over years of infection, developing unusual features such as high mutation rates in the subset of individuals that acquire breadth. Using single-cell RNA sequencing, single-cell proteomics, and plasma neutraliz...

Topics

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• AIDS Vaccines
• Antibodies, Neutralizing
• Antigenic Variation
• HIV Antibodies
• HIV Envelope Protein gp120
• HIV Research and Treatment
• Monoclonal and Polyclonal Antibodies Research
• Neutralization Tests

Identifiers and source

Literature Corpus work

4e3e3707-610b-5f91-9272-c18045949c3b

DOI

10.64898/2026.06.05.730519