Article

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

2025-08-27

Abstract excerpt

Administration of HIV-1 neutralizing antibodies can suppress viremia and prevent infection in vivo . However, clinical use is challenged by broad envelope sequence diversity and rapid emergence of viral escape 1–9 . Here, we performed single B cell profiling of 32 top HIV-1 elite neutralizers to identify broadly neutralizing antibodies (bNAbs) with highest potency and breadth for clinical application. From 831 e...

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Literature Corpus work: 533e7faa-e18f-5544-a967-11e01e76ab67
DOI: 10.1101/2025.08.27.672638

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