Article

Multifaceted B-cell response to transient HIV viraemia in elite controllers

2024-12-28

Abstract excerpt

<h4>ABSTRACT</h4> Chronic HIV infection drives B-cell dysfunction associated with the accumulation of tissue-like memory (TLMs) and activated memory B cells (MBCs) but decline in resting memory B cells. TLMs express multiple inhibitory receptors and lack response to soluble antigens. However, their origin and the mechanisms driving their expansion in HIV infection remain unclear. By using bulk BCR sequencing of m...

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Literature Corpus work: d917273e-3229-5a60-bf89-4cf987a270f5
DOI: 10.1101/2024.12.28.630596

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