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Establishment of a Systemic Lupus Erythematosus Mouse Model in Humanized CD3/CD19 Mice and Evaluation of the Efficacy of a Human Bispecific Antibody

2025-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease affecting multiple organ systems and is considered one of the most severe autoimmune diseases worldwide, significantly impacting women’s health. B cells play a crucial role in disease pathogenesis by becoming abnormally activated and producing autoantibodies that attack the body’s normal tissues, leading to inflammation and organ...

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Literature Corpus work
4e3c47a5-9b0f-59da-9e40-f9732a0c50d7
DOI
10.1101/2025.08.21.668572
Open publication

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