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Article

Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune System

2026-05-12

Abstract excerpt

<h4>Introduction</h4> Immune checkpoint inhibitors (ICIs) enhance antitumor responses by blocking inhibitory receptors, including PD-1 and CTLA-4. Overactivation can trigger systemic toxicity akin to autoimmune diseases, including kidney manifestations. We sought to 1) profile immune signaling and 2) interrogate potential mechanisms of ICI-related kidney injury in a Human Immune System (HIS) tumor-bearing mouse m...

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Literature Corpus work
5812237d-14cb-5d02-92da-1ed71ff80653
DOI
10.64898/2026.05.07.723340
Open publication

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Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune SystemDOI 10.64898/2026.05.07.723340
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