Article

An In Vivo Method for Diversifying the Functions of Therapeutic Antibodies

2020-12-12

Abstract excerpt

V(D)J recombination generates mature B cells that express huge repertoires of primary antibodies as diverse immunoglobulin heavy (IgH) and light chains (IgL) of their B cell antigen receptors (BCRs). Cognate antigen binding to BCR variable region domains activates B cells into the germinal center (GC) reaction in which somatic hypermutation (SHM) modifies primary variable region-encoding sequences, with subsequent...

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Literature Corpus work: 849d95d6-580c-5d4d-b40b-e1545552773b
DOI: 10.1101/2020.12.12.421834

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