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Article

A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy.

PloS one - 1 Jan 2021

Crespo Joel, Koh Yi Ting, Hu Ningjie, Moore Paul A, Bonvini Ezio, Glasebrook Andrew L, Martin Andrea P, Benschop Robert J

Abstract excerpt

Pre-clinical murine models are critical for translating drug candidates from the bench to the bedside. There is interest in better understanding how anti-human CD3 therapy works based on recent longitudinal studies of short-term administration. Although several models have been created in this pursuit, each have their own advantages and disadvantages in Type-1 diabetes. In this study, we report a murine genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33596227
DOI: 10.1371/journal.pone.0245917
PMCID: PMC7888618

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