Article
Peripheral CD19hi B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.
Scientific reports - 24 Oct 2017
Liu Zhicui, Zeng Weihong, Huang Xiangyang, Wang Shujun, Zheng Jie, Pan Meng, Wang Ying
Abstract excerpt
Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19hi B cell population existing in the periphery of SLE and pemphigus...
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