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Article

A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery.

mAbs - 1 Jan 2000

Duvall Marcus, Bradley Norma, Fiorini Ryan N

Abstract excerpt

A new technology has been developed that allows human antibodies to be quickly generated against virtually any antigen. Using a novel process, naïve human B cells are isolated from tonsil tissue and transformed with efficiency up to 85%, thus utilizing a large portion of the human VDJ/VJ repertoire. Through ex vivo stimulation, the B cells class switch and may undergo somatic hypermutation, thus producing a human...

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Share to Antigens
Share to Biotechnology
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Immunoglobulin Class Switching

Share to Immunoglobulin G

Share to Leukocytes, Mononuclear

Share to Palatine Tonsil

Source

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Identifiers

PMID: 21285537
DOI: 10.4161/mabs.3.2.14774
PMCID: PMC3092621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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