Article

LegoBody: facile generation of bispecific and multi-specific antibodies

2019-12-27

Abstract excerpt

Bispecific and multi-specific antibodies are capable of recognizing multiple ligands simultaneously or synergistically, creating complex biological interactions not achievable by monoclonal antibodies, thus expanding opportunities for novel therapy development. With the large number of monoclonal antibodies either approved or under clinical development, there are numerous opportunities to combine their specificiti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f70b1b28-5092-5a81-8c09-6c99b5c438c3
DOI: 10.1101/2019.12.25.888586

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LegoBody: facile generation of bispecific and multi-specific antibodiesDOI 10.1101/2019.12.25.888586Read

A Plug-and-Play Approach for the De Novo Generation of Dually Functionalised BispecificsSemantic proximity Read

Antibody Structure and Function: The Basis for Engineering TherapeuticsSemantic proximity Read

Mechanism of Action and Pharmacokinetics of Approved Bispecific AntibodiesSemantic proximity Read

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodiesSemantic proximity Read

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cellsSemantic proximity Read

Monoclonal antibodies: From magic bullet to precision weaponSemantic proximity Read

A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing.Semantic proximity Read

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.Semantic proximity Read

Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.Semantic proximity Read

Principles and Current Clinical Landscape of Multispecific Antibodies against CancerSemantic proximity Read

Next generation Fc scaffold for multispecific antibodiesSemantic proximity Read

Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface.Semantic proximity Read