Article
Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.
PLoS pathogens - 1 Apr 2021
Tong Orion, Duette Gabriel, O'Neil Thomas R, Royle Caroline M, Rana Hafsa, Johnson Blake, Popovic Nicole, Dervish Suat, Brouwer Michelle A E, Baharlou Heeva, Patrick Ellis, Ctercteko Grahame, Palmer Sarah, Lee Eunok, Hunter Eric, Harman Andrew N, Cunningham Anthony L, Nasr Najla
Abstract excerpt
Although HIV infection inhibits interferon responses in its target cells in vitro, interferon signatures can be detected in vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic cells (pDCs). In this study, we examined the physiological contributions of pDCs to early HIV acquisition using coculture models of pDCs with myeloid DCs, macrophages and the resting central, transitional and...
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