Article
Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells.
PloS one - 1 Jan 2011
Yonkers Nicole L, Rodriguez Benigno, Asaad Robert, Lederman Michael M, Anthony Donald D
Abstract excerpt
BACKGROUND: HIV infection is characterized by ineffective anti-viral T-cell responses and impaired dendritic cell (DC) functions, including response to Toll-Like Receptor (TLR) ligands. Because TLR responsiveness may affect a host's response to virus, we examined TLR ligand induced Myeloid and Plasmacytoid DC (MDC and PDC) activation of naïve T-cells in HIV+ subjects. METHODS: Freshly purified MDC and PDC...
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