Article

HIV-1 Reprograms CD4 T Cell Responses by Impairing Antigen-specific Communication with Dendritic Cells

2025-08-15

Abstract excerpt

HIV-1 infection causes general dysfunction of adaptive immune cells that persists even under therapy but the underlying mechanisms remain elusive. Antigen-specific interactions of the main target cells of HIV, CD4 T cells, with dendritic cells (DCs) orchestrate global T cell responses and convey help to CD8 T cells. Here we report that HIV-1, by virtue of its pathogenesis factor Nef, impairs activation and transcr...

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Literature Corpus work: d3ae4927-292a-5209-a9b7-c6d799cbccdc
DOI: 10.1101/2025.08.14.670333

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