Article
Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype.
The Journal of clinical investigation - 1 Mar 2011
O'Brien Meagan, Manches Olivier, Sabado Rachel Lubong, Baranda Sonia Jimenez, Wang Yaming, Marie Isabelle, Rolnitzky Linda, Markowitz Martin, Margolis David M, Levy David, Bhardwaj Nina
Abstract excerpt
Plasmacytoid DCs (pDCs) are innate immune cells that are specialized to produce IFN-α and to activate adaptive immune responses. Although IFN-α inhibits HIV-1 replication in vitro, the production of IFN-α by HIV-activated pDCs in vivo may contribute more to HIV pathogenesis than to protection. We have now shown that HIV-stimulated human pDCs allow for persistent IFN-α production upon repeated stimulation, express...
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