Article

Local joint testing improves power and identifies missing heritability in association studies

2016-02-18

Abstract excerpt

There is mounting evidence that complex human phenotypes are highly polygenic, with many loci harboring multiple causal variants, yet most genetic association studies examine each SNP in isolation. While this has lead to the discovery of thousands of disease associations, discovered variants account for only a small fraction of disease heritability. Alternative multi-SNP methods have been proposed, but issues such...

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Literature Corpus work: abc4379c-03b9-5721-a443-439bd6154b13
DOI: 10.1101/040089

Open publication

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