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COMBAT: A Combined Association Test for Genes Using Summary Statistics.

Genetics - 1 Nov 2017

Wang Minghui, Huang Jianfei, Liu Yiyuan, Ma Li, Potash James B, Han Shizhong

Abstract excerpt

Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Traditional analysis of GWAS typically examines one marker at a time, usually single nucleotide polymorphisms (SNPs), to identify individual variants associated with a disease. However, due to the small effect sizes of common variants, the power to detect individual risk variants is...

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PMID: 28878002
DOI: 10.1534/genetics.117.300257
PMCID: PMC5676236

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