Article

A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity

2024-06-19

Abstract excerpt

NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute the immune response triggered by disease resistance proteins, also known as sensor NLRs. The structure of the resting state of NbNRC2 was recently revealed to be a homodimer. However, the sensor-activated state has not yet been elucidated. In this study, we used cryo-EM to determine the structure of sensor-activ...

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Literature Corpus work: 4e074cf9-6033-5252-bfde-710f19416c5b
DOI: 10.1101/2024.06.18.599586

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A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunityDOI 10.1101/2024.06.18.599586Read

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