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Article

Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2022

Ohto Umeharu, Kamitsukasa Yukie, Ishida Hanako, Zhang Zhikuan, Murakami Karin, Hirama Chie, Maekawa Sakiko, Shimizu Toshiyuki

Abstract excerpt

SignificanceThe nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) is a pattern recognition receptor that forms an inflammasome. The cryo-electron microscopy structure of the dodecameric form of full-length NLRP3 bound to the clinically relevant NLRP3-specific inhibitor MCC950 has established the structural basis for the oligomerization-mediated regulation of NLRP3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35254907
DOI: 10.1073/pnas.2121353119
PMCID: PMC8931350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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