Article

Bypassing PELO-mediated ATPase activation of NLR is a common pathogenic cause of <i>NLR</i> -associated autoinflammatory diseases

2024-01-23

Abstract excerpt

<h4>SUMMARY</h4> Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) constitute the largest family of pattern recognition receptors. These receptors are master regulators of innate immunity. Recently, PELO-driven ATPase activation of NLRs was demonstrated as a critical step in NLR activation. Linkage studies in human with various inherited autoinflammatory conditions have revealed an extensi...

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Literature Corpus work: 2fc193ea-8a4f-55e0-9442-3a82bbffdc57
DOI: 10.1101/2024.01.20.576395

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