Article

Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer’s mouse models

2022-04-28

Abstract excerpt

Conversion of astroglia into functional neurons has been considered as a promising therapeutic strategy for neurodegenerative diseases. Recent studies reported that downregulation of the RNA binding protein, PTBP1, converts astrocytes into neurons in situ in multiple mouse brain regions, consequently improving pathological phenotypes associated with Parkinson’s disease, RGC loss, and aging. Here, we demonstrate th...

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Literature Corpus work: 4e00c116-ac75-5735-a478-c196e66e768f
DOI: 10.1101/2022.04.27.489696

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