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Article

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Stem cell reports - 13 Jan 2015

Caiazzo Massimiliano, Giannelli Serena, Valente Pierluigi, Lignani Gabriele, Carissimo Annamaria, Sessa Alessandro, Colasante Gaia, Bartolomeo Rosa, Massimino Luca, Ferroni Stefano, Settembre Carmine, Benfenati Fabio, Broccoli Vania

Abstract excerpt

Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This approach is rapid and simple, generating the cell types of interest in one step. However, it remains unknown whether this technology can be applied to convert fibroblasts into astrocytes, the third neural lineage. Astrocytes play...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25556566
DOI: 10.1016/j.stemcr.2014.12.002
PMCID: PMC4297873

Genes

NFIA
NFIB
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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