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Selective neuronal restoration of progranulin does not prevent the frontotemporal dementia like-phenotype of progranulin knockout mice.

Journal of neuroinflammation - 10 Jan 2026

Weyer Marc-Philipp, Hahnefeld Lisa, Franck Luisa, Angioni Carlo, Klein Matthias, Geisslinger Gerd, Schäfer Michael K E, Tegeder Irmgard

Abstract excerpt

Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor produced mainly by neurons and microglia in the central nervous system. Progranulin haploinsufficiency causes frontotemporal dementia (FTD). It is unclear to what extent neuronal versus microglial PGRN deficiency contributes to FTD pathology. In this study, we restored progranulin in neurons in progranulin knockout mice using Nestin-driven...

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Brain
Frontotemporal Dementia
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic

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PMID: 41520115
DOI: 10.1186/s12974-025-03665-3
PMCID: PMC12836895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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