Article

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

2020-02-19

Abstract excerpt

G-quadruplexes (G4), non-canonical DNA structures, are involved in several essential processes. Stabilization of G4 structures by small compounds (G4 ligands) affects almost all DNA transactions, including telomere maintenance and genomic stability. Here, thanks to a powerful and unbiased genetic approach, we identify topoisomerase 2-alpha (TOP2A) as the main effector of cell cytotoxicity induced by CX5461, a G4 l...

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Literature Corpus work: 3f347548-2d61-5beb-be51-51ddefa07e16
DOI: 10.1101/2020.02.18.953851

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