Article
Chemotherapy and the somatic mutation burden of sperm.
JCI insight - 23 Jun 2025
Picciotto Shany, Arenas-Gallo Camilo, Toren Amos, Mehrian-Shai Ruty, Daly Bryan, Rhodes Stephen, Prunty Megan, Liu Ruolin, Bohorquez Anyull, Grońska-Pęski Marta, Melanaphy Shana, Callum Pamela, Lassen Emilie, Skytte Anne-Bine, Obeng Rebecca C, Barbieri Christopher, Gallogly Molly, Cooper Brenda, Daunov Katherine, Beard Lydia, van Besien Koen, Halpern Joshua, Pan Quintin, Evrony Gilad D, Adalsteinsson Viktor A, Shoag Jonathan E
Abstract excerpt
Many chemotherapeutic agents impair cancer growth by inducing DNA damage. The impact of these agents on mutagenesis in normal cells, including sperm, is largely unknown. Here, we applied high-fidelity duplex sequencing to 94 samples from 36 individuals exposed to diverse chemotherapies and 32 controls. We found that in many of the sperm samples from men exposed to chemotherapy, the mutation burden was elevated as...
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